Mouse Anti-Chicken MCAM-UNLB MBS673956 from MyBioSource.com

Product Specs
ItemMouse Anti-Chicken MCAM-UNLB
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS673956
Quantity0.5 mg
ApplicationsFlow Cytometry; Immunohistochemistry (Acetone Fixed/Frozen Sections); Immunoprecipitation
Conjugate/TagUnconjugated
FormatPurified (UNLB) Antibody
ReactivityChicken
TargetMCAM
IsotypeIgG2b kappa
Molecular Weight71,607 Da
CloneC264
HostMouse
Antibody TypeSecondary
ImmunogenChicken MCAM, Mr 98 kDa (protein core ?84 kDa)
Chicken MCAM, a member of the immunoglobulin superfamily of cell surface receptors, consists of the V-V-C2-C2-C2 Ig domains. It is a single chain glycoprotein with three mRNA splice variants. One has a short cytoplasmic tail, another has a long tail, and the third seems to lack transmembrane and cytoplasmic regions. It is highly homologous to gicerin, a molecule involved in neurite outgrowth and Wilm's kidney tumor progression in the chicken, and to the human melanoma progression molecule MUC18. Chicken MCAM is expressed by c-kit+ hematopoietic progenitor cells in embryonic bone marrow, thymocytes, and capillary endothelial cells. MCAM-expressing cells sorted from bone marrow are enriched in progenitors capable of differentiating into T cells when transferred into the appropriate thymic microenvironment. MCAM has been proposed to be involved in cellular adhesion and homing processes.1
NCBI Full Gene Namemelanoma cell adhesion molecule
NCBI Gene AliasesCD146, MUC18
ClonalityMonoclonal